Test Directory
5406 Factor II (Prothrombin) Mutation
Specimen Type
Specimen Stability
Reference Range
Whole blood-Lavender top tube
8 days 2-8°C
Not Detected
Specimen Requirements
Full 7-10mL tube of Whole blood
Method
PCR-Invader
Schedule
Tues, Thurs, Sat
Turn-Around Time
2-3 Days
Instructions/Notes
Clinical Utility
The Factor II (Prothrombin) G20210A mutation is the second most common genetic abnormality of the coagulation system, after Factor V Leiden, and is associated with elevated plasma prothrombin levels and increased risk of venous thrombosis. This mutation is present in 18% of patients with family history of venous thrombosis and more than 6% of patients with deep venous thrombosis. Heterozygous individuals with this mutation have an approximately 3-fold increased risk of venous thrombosis. Other predisposing factors include pregnancy related venous thrombosis, intrauterine growth retardation, preeclampsia, and unexplained fetal loss (N Engl J Med. 2001 Apr 19;344(16):1222-31). Homozygosity for this mutation is very rare and the increased risk for these individuals is not known.
CPT Codes
83891, 83892, 83898, 83896x3, 83903, 83908, 83912; NOTE: New 2013 CPT: 81240
