Preferred amount: 1.0 mL Serum
Minimum amount: 0.5 mL Serum
Test performed using Fujirubio Diagnostics, Inc. HE4 enzyme immunometric assay
1-3 days (except weekends)
HE4 is a tumor marker that can complement CA 125 for monitoring recurrence or progression of ovarian cancer. Elevated HE4 levels are associated with ovarian cancer but are not specific for the disease, and therefore the assay should not be used for screening. A change in HE4 level of >25% is considered significant. (package insert Fujirubio Diagnostics 2008). An increase of >25% suggests disease progression or recurrence. Serial testing of HE4 results should be used in conjunction with other clinical methods for monitoring ovarian cancer. HE4 is less sensitive/specific in mucinous or germ-cell ovarian cancer. The combination of HE4 and CA 125 serology might increase sensitivity and specificity for the detection of early ovarian cancer.
Values obtained with different assay methods should not be used interchangeably.
Tumor Biol 2011;32:1087-95.