Test Directory

7293 Celiac Disease Evaluatr(TM) With IgA

Specimen Type
Specimen Stability
Reference Range
Serum
14 Days, Refrigerated
30 Days, Frozen
See Report

Specimen Requirements

Specimen Type: Serum
Container: 2 Serum Separator Tube (SST)s
Temperature: Refrigerated
Preferred Vol: 4.00 mL
Min Vol: 2.00 mL

Method

Immunoturb, Enzyme Immunoassay (EIA),Indirect fluorescent antibody (IFA)

Schedule

Tuesday - Saturday

Turn-Around Time

Send-Out

Instructions/Notes

Clinical Utility

Comprehensive evaluation of gluten sensitivity characteristic of Celiac disease. A high percentage of patients with Celiac disease also have IgA deficiency. Celiac disease or gluten sensitive entropathy is a chronic condition that damages the lining of the small intestine and results in a malabsorption syndrome. Detection of antibodies to gliadin, one of the major protein components of gluten, is useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

CPT Codes

82784, 83516, 86255

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