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Test Directory

7319 Methylmalonic Acid

Specimen Type
Specimen Stability
Reference Range
Serum
30 Days, Ambient
30 Days, Refrigerated
Frozen-30 Days
< 0.40 umol/L

Specimen Requirements

Specimen Type: Serum
Container: 1 Serum Separator Tube (SST)
Temperature: Frozen
Preferred Vol: 3.00 mL
Min Vol: 2.00 mL

Method

Gas Chromatography/Mass Spectrometry (GC/MS)

Schedule

Tuesday - Saturday

Turn-Around Time

Send-Out

Instructions/Notes

Frozen specimen is preferred.

Clinical Utility

Methylmalonic acid is a very sensitive indicator of Vitamin B12 deficiency at the tissue level. Mildly elevated levels (0.4-1.0 umol/L) are seen in patients with decreased renal function. Extremely high levels (>20 umol/L) are indicative of methylmalonic acidemia, an inborn error of metabolism disorder

CPT Codes

83921

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