Test Directory

7358 Maternal Serum AFP Quadscreen

Specimen Type
Specimen Stability
Reference Range
14 Hours, Ambient
2 Months, Frozen
5 Days, Refrigerated
See Report

Specimen Requirements

Specimen Type: Serum
Container: 2 Serum Separator Tube (SST)s
Temperature: Refrigerated
Preferred Vol: 5.00 mL
Min Vol: 3.00 mL


Immunochromatographic Membrane Assay (ICMA), Chemiluminescence (CL)


Tuesday - Sunday

Turn-Around Time



Maternal information required.

Clinical Utility

The performance of this test varies with maternal age and other clinical parameters. Recent research suggests that second trimester maternal serum screening of alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin and inhibin A (the Quad Screen) has 81% sensitivity for Down syndrome detection and a false-positive rate of 7%. This use is considered to be investigational. Follow-up testing is recommended for patients when the calculated second trimester Down syndrome risk is greater than or equal to 1: 270. Normal serum AFP levels for neural tube defects (NTD) are less than 2.0 multiples of the median (MoM). Normal values exclude approximately 95% of cases of anencephaly, 80% of cases of spina bifida, and 85% of ventral wall defects. Closed dysraphic states and small defects generally constitute the group in which total exclusion is not possible.

CPT Codes

82105, 82677, 84702

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