Test Directory

7358 Maternal Serum AFP Quadscreen

Specimen Type
Specimen Stability
Reference Range
Serum
14 Hours, Ambient
2 Months, Frozen
5 Days, Refrigerated
See Report

Specimen Requirements

Specimen Type: Serum
Container: 2 Serum Separator Tube (SST)s
Temperature: Refrigerated
Preferred Vol: 5.00 mL
Min Vol: 3.00 mL

Method

Immunochromatographic Membrane Assay (ICMA), Chemiluminescence (CL)

Schedule

Tuesday - Sunday

Turn-Around Time

Send-Out

Instructions/Notes

Maternal information required.

Clinical Utility

The performance of this test varies with maternal age and other clinical parameters. Recent research suggests that second trimester maternal serum screening of alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin and inhibin A (the Quad Screen) has 81% sensitivity for Down syndrome detection and a false-positive rate of 7%. This use is considered to be investigational. Follow-up testing is recommended for patients when the calculated second trimester Down syndrome risk is greater than or equal to 1: 270. Normal serum AFP levels for neural tube defects (NTD) are less than 2.0 multiples of the median (MoM). Normal values exclude approximately 95% of cases of anencephaly, 80% of cases of spina bifida, and 85% of ventral wall defects. Closed dysraphic states and small defects generally constitute the group in which total exclusion is not possible.

CPT Codes

82105, 82677, 84702

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