Specimen Type: Citrated Plasma
Container: 2 Light Blue Top Tubes
Preferred Vol: 4.00 mL
Min Vol: 2.00 mL
Monday - Saturday
STRICT FROZEN. Separate Plasma and Freeze within 1 hour of collection.
Lupus Anticoagulants (LA) are members of a family of antibodies with phospholipid specificity. LA may be defined as an immunoglobulin (S), IgG or IgM or a mixture of both, that interferes with one or more of the invitro phospholipid (PL)dependent tests of coagulation. These antibodies are not associated with a hemorrhagic diathesis, but rather have been linked to thrombotic events. It is not known whether the antibody is causative, coincidental or a consequence of the thrombosis. In addition to thrombosis, other clinical complications have been associated with the presence of LA. These include strokes, nonbacterial thrombotic endocarditis, livedo reticularis and a variety of obstetrical complications such as intrauterine fetal death, recurrent spontaneous abortion, fetal growth retardation, early onset preeclampsia and chorea gravidarum.