IHC: Bcl-1 (Cyclin D1) IHC: Bcl-1 (Cyclin D1)

Specimen Type Specimen Stability Reference Range
Paraffin block N/A N/A

Specimen Requirements

Paraffin block or wet tissue

Method

Immunohistochemistry (IHC)

Schedule

Mon-Fri

Turn-Around Time

24 hrs

Instructions/Notes

Formalin-Fixed, Paraffin-Embedded

Clinical Utility

IGH/CCND1 is a cell cycle regulatory protein identified through the 11;14 translocation of its genein mantle cell lymphomas (MCL). It is a nuclear protein detectable in paraffin sections and isfound in the majority of mantle cell lymphomas. Hairy cell leukemia and plasmacytoma may alsoexpress IGH/CCND1, albeit with a weaker signal.

CPT Codes

88342

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