| Specimen Type | Specimen Stability | Reference Range |
| Serum-SST | 7 days 2-8°C | See Report |
Specimen Requirements
Preferred amount: 4.0 mL Serum
Minimum amount: 2.0 mL Serum |
Method
Immunoturb, EIA, IFA
|
Schedule
*Sendout: Tue-Sat
|
Turn-Around Time
Reported same day following testing
|
Instructions/Notes
Centrifuge required?: Yes
|
Clinical Utility
Comprehensive evaluation of gluten sensitivity characteristic of Celiac disease. A high percentage of patients with Celiac disease also have IgA deficiency. Celiac disease or gluten sensitive entropathy is a chronic condition that damages the lining of the small intestine and results in a malabsorption syndrome. Detection of antibodies to gliadin, one of the major protein components of gluten, is useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
|
CPT Codes
82784, 83516x3, 86255x2
|
Related Materials |