5406 Factor II (Prothrombin) Mutation

Specimen Type Specimen Stability Reference Range
Whole Blood 8 Days 2 - 8°C Not Detected

Specimen Requirements

Specimen Type: Whole Blood
Container: 1 Lavender Top Tube
Temperature: Refrigerated
Preferred Vol: 2.00 mL
Min Vol: 2.00 mL

Method

PCR-Invader

Schedule

Tues, Thurs, Sat

Turn-Around Time

2-3 Days

Instructions/Notes

Full tube of Whole blood

Clinical Utility

The Factor II (Prothrombin) G20210A mutation is the second most common genetic abnormality of the coagulation system, after Factor V Leiden, and is associated with elevated plasma prothrombin levels and increased risk of venous thrombosis. This mutation is present in 18% of patients with family history of venous thrombosis and more than 6% of patients with deep venous thrombosis. Heterozygous individuals with this mutation have an approximately 3-fold increased risk of venous thrombosis. Other predisposing factors include pregnancy related venous thrombosis, intrauterine growth retardation, preeclampsia, and unexplained fetal loss (N Engl J Med. 2001 Apr 19;344(16):1222-31). Homozygosity for this mutation is very rare and the increased risk for these individuals is not known.

CPT Codes

81240, 83891 X 2, 83892 X 2, 83896 X 2, 83898 X 2, 83903 X 2, 83908 X 2, 83912 X 2

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